原创力文档A novel phenotype of nonsteroidal anti-inflammatory drug hypersensitivity the high-risk patient.docVIP
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A novel phenotype of nonsteroidal anti-inflammatory drug hypersensitivity the high-risk patient
ORIGINALARTICLE
ANovelPhenotypeofNonsteroidalAnti-Inflammatory
DrugHypersensitivity
TheHigh-RiskPatient
MarioSa′nchez-Borges,1,2 ArnaldoCapriles-Hulett,2,3 andFernanCaballero-Fonseca2,3
of these reactions are mediated by speci?c immunologic
Background:Some nonsteroidal anti-in?ammatory drug (NSAID)Y
mechanismsandithasbeenpostulatedthattheyarecausedby
hypersensitivepatientsdevelopadversereactionswhenchallengedwith
inhibition of the isoenzyme cyclooxygenase 1 (COX-1),
weakcyclooxygenase1(COX-1)inhibitors.
leadingtoexcessiveproductionofcysteinylleukotrienesand
adecreasedsynthesisofprostaglandin
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