A novel preclinical model for rheumatoid arthritis research.docVIP

Petersen and Yu Arthritis Research Therapy 2010, 12:148 /content/12/6/148 EDITORIAL A novel preclinical model for rheumatoid arthritis research Frank Petersen and Xinhua Yu* See related research by Vierboom et al., /content/12/5/R200 Abstract Based on increasing knowledge on the pathogenesis of rheumatoid arthritis (RA), more and more potential therapeutics have been developed. To evaluate their therapeutic e?cacy, safety and toxicity, appropriate animal models are required. Although rodent models of RA have been extensively used for preclinical evaluation, the di?erences between rodents a