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A peptidyl-glucosamine derivative affects IKKα kinase activity in human chondrocytes
Scottod’Abuscoetal.ArthritisResearchTherapy2010,12:R18
/content/12/1/R18
RESEARCH ARTICLE
OpenAccess
Apeptidyl-glucosaminederivativeaffectsIKKa
kinaseactivityinhumanchondrocytes
AnnaScottod’Abusco1*,LauraPoliti1,CesareGiordano2,RobertoScandurra1
Abstract
Introduction:Nuclearfactor-B(NF-B)transcriptionfactorregulatesseveralcellsignalingpathways,suchas
differentiationandinflammation,whicharebothalteredinosteoarthritis.InhibitorBkinase(IKK)aandIKKbare
kinasesinvolvedintheactivationoftheNF-Btranscriptionfactor.Theaimofthepresentstudywastodetermine
theeffectsofglucosamine(GlcN),whichisadmini
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