原创力文档A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee.docVIP
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A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
Cohenetal.ArthritisResearchTherapy2011,13:R125
/content/13/4/R125
RESEARCH ARTICLE
OpenAccess
Arandomized,double-blindstudyofAMG108
(afullyhumanmonoclonalantibodytoIL-1R1)
inpatientswithosteoarthritisoftheknee
StanleyBCohen1*,SusannaProudman2,AlanJKivitz3,FrancisXBurch4,JohnPDonohue5,DeborahBurstein6,
Yu-NienSun7,ChristopherBanfield8,MichaelSVincent9,LiyunNi10andDebraJZack9
Abstract
Introduction:AMG108isafullyhuman,immunoglobulinsubclassG2(IgG2)monoclonalantibodythatbindsthe
humaninterleukin-1(IL-1)receptortype1,inhibitingtheactivityofIL-1aandIL-1b.Inpreclinicalstudies,IL-1
inhibitionwassho
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