原创力文档A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines.docVIP
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A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines
Hessonetal.BiologicalProceduresOnline2012,14:5
/content/14/1/5
Biological Procedures
Online
RESEARCH
OpenAccess
Areinvestigationofsomatichypermethylationat
thePTENCpGislandincancercelllines
LukeBHesson1,DeborahPackham1,EmilyPontzer2,3,PaulineFunchain2,CharisEng2,3 andRobynLWard1*
Abstract
Background:PTENisanimportanttumoursuppressorgenethatismutatedinCowdensyndromeaswellas
varioussporadiccancers.CpGislandhypermethylationisanotherroutetotumoursuppressorgeneinactivation,
however,theliteratureregardingPTENhypermethylationincanceriscontroversial.Furthermore,investigationof
themethylationsta
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