原创力文档A role for low-abundance miRNAs in colon cancer the miR-206Krüppel-like factor 4 (KLF4) axis.docVIP
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A role for low-abundance miRNAs in colon cancer the miR-206Krüppel-like factor 4 (KLF4) axis
Parasramkaetal.ClinicalEpigenetics2012,4:16
/content/4/1/16
RESEARCH
OpenAccess
Aroleforlow-abundancemiRNAsincoloncancer:
themiR-206/Krüppel-likefactor4(KLF4)axis
MansiAParasramka1,WMohaizaDashwood1,RongWang1,HassaanHSaeed1,DavidEWilliams1,2,EmilyHo1,3
andRoderickHDashwood1,2,4*
Abstract
Background:MicroRNAs(miRNAsormiRs)areshortnon-codingRNAsthataffecttheexpressionofgenesinvolved
innormalphysiology,butthatalsobecomedysregulatedincancerdevelopment.Inthelattercontext,studiesto
datehavefocusedonhigh-abundancemiRNAsandtheirtargets.Wehypothesizedthatamongthepoolof
low-abundancemiRNAsaresomewitht
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