A Short Synthesis of the Main Lactone Ketal Backbone Present in Saudin.docVIP

321 Molecules 2000, 5 A Short Synthesis of the Main Lactone Ketal Backbone Present in Saudin Guillermo R. Labadie, Raquel M. Cravero and Manuel Gonzalez Sierra IQUIOS (Instituto de Quimica Organica de Syntesis)-CONICET- Facultad de Cs. Bioquimicas y Far- maceuticas-Universidad Nacional de Rosario Suipacha 531- 2000 Rosario-Santa Fe, Argentina E-mail: iquiosra@citynet.net.ar Abstract: We are describing a brief stereospecific synthesis of a model compound related to Saudin, with a lactone ketal backbone present in the natural product starting from a tricyclic epoxiketal. Introduction Saudin