A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia.docVIP

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A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia.doc

A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia

Neelametal.BMCPsychiatry2011,11:139 /1471-244X/11/139 RESEARCH ARTICLE OpenAccess Asystematicreviewandmeta-analysisof neurologicalsoftsignsinrelativesofpeoplewith schizophrenia KishenNeelam1,2,3*,DeepakGarg4andMaxMarshall1,3 Abstract Background:Neurologicalsoftsignsaresubtlebutobservableimpairmentsinmotorandsensoryfunctionsthat arenotlocalizedtoaspecificareaofthebrain.Neurologicalsoftsignsarecommoninschizophrenia.Ithasbeen establishedthatsoftsignsmeettwooffivecriteriaforanendophenotype,namely:associationwiththeillness,and stateindependence.Thisreviewinvestigatedwhethersoftsignsmetafurthercr

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