A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia.docVIP
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A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia
Neelametal.BMCPsychiatry2011,11:139
/1471-244X/11/139
RESEARCH ARTICLE
OpenAccess
Asystematicreviewandmeta-analysisof
neurologicalsoftsignsinrelativesofpeoplewith
schizophrenia
KishenNeelam1,2,3*,DeepakGarg4andMaxMarshall1,3
Abstract
Background:Neurologicalsoftsignsaresubtlebutobservableimpairmentsinmotorandsensoryfunctionsthat
arenotlocalizedtoaspecificareaofthebrain.Neurologicalsoftsignsarecommoninschizophrenia.Ithasbeen
establishedthatsoftsignsmeettwooffivecriteriaforanendophenotype,namely:associationwiththeillness,and
stateindependence.Thisreviewinvestigatedwhethersoftsignsmetafurthercr
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