Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza a controlled laboratory study.docVIP

Schouten et al. Critical Care 2010, 14:R65 /content/14/2/R65 RESEARCH Open Access Activated protein C ameliorates coagulopathy but Research does not influence outcome in lethal H1N1 influenza: a controlled laboratory study Marcel Schouten*1,2, Koenraad F van der Sluijs2,3,4, Bruce Gerlitz5, Brian W Grinnell5, Joris JTH Roelofs6, Marcel M Levi7, Cornelis van t Veer1,2 and Tom van der Poll1,2,7 Abstract Introduction: Influenza accounts for 5 to 10% of community-acquired pneumonias and is a major cause of mortality. Sterile and bacterial lung injuries are associated with procoagulant and in