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Activated protein C in septic shock a propensity-matched analysis
Sadakaetal.CriticalCare2011,15:R89
/content/15/2/R89
RESEARCH
OpenAccess
ActivatedproteinCinsepticshock:
apropensity-matchedanalysis
FaridSadaka*,JacklynO’Brien,MatthewMigneron,JulieStortz,AlexanderVanston,RobertWTaylor
Abstract
Introduction:TheuseofhumanrecombinantactivatedproteinC(rhAPC)forthetreatmentofseveresepsis
remainscontroversialdespitemultiplereportedtrials.TheefficacyofrhAPCremainsamatterofdispute.We
hypothesizedthatpatientswithsepticshockwhoweretreatedwithrhAPChadanimprovedin-hospitalmortality
comparedtopatientswithsepticshockwithsimilaracuitywhodidnotreceiverhAPC.
Methods:Thisre
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