原创力文档Activation of factor VII-activating protease in human inflammation a sensor for cell death.docVIP
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Activation of factor VII-activating protease in human inflammation a sensor for cell death
Stephanetal.CriticalCare2011,15:R110
/content/15/2/R110
RESEARCH
OpenAccess
ActivationoffactorVII-activatingproteasein
humaninflammation:asensorforcelldeath
FemkeStephan1,JanAHazelzet2,IngridBulder1,MarjaABoermeester3,JWOliviervanTill3,TomvanderPoll4,
WalterAWuillemin5,LucienAAarden1andSachaZeerleder1,6*
Abstract
Introduction:Celldeathisacentraleventinthepathogenesisofsepsisandisreflectedbycirculating
nucleosomes.Circulatingnucleosomesweresuggestedtoplayanimportantroleininflammationandwere
demonstratedtocorrelatewithseverityandoutcomeinsepsispatients.Werecentlyshowedthatplasmacan
releasenucl
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