Adoptive transfer of splenocytes to study cell-mediated immune responses in hepatitis C infection using HCV transgenic mice.docVIP

Naasetal.ComparativeHepatology2010,9:7 /content/9/1/7 RESEARCH OpenAccess Adoptivetransferofsplenocytestostudy cell-mediatedimmuneresponsesinhepatitis CinfectionusingHCVtransgenicmice TurayaNaas1,2,MasoudGhorbani1,5,CatalinaSoare1,2,NicoleScherling1,2,RudyMuller4,PeymanGhorbani1,2, FranciscoDiaz-Mitoma1,2,3* Abstract Background:HepatitisCvirus(HCV)isamajorcauseofchronichepatitisandahealthproblemaffectingover170 millionpeoplearoundtheworld.WepreviouslystudiedtransgenicmicethatexpressHCVCore,Envelope1and Envelope2proteinspredominantlyintheliver,resultinginsteatosis,liverandlymphoidtumors,andhe