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AICAR inhibits ceramide biosynthesis in skeletal muscle
Ericksonetal.DiabetologyMetabolicSyndrome2012,4:45
/content/4/1/45
DIABETOLOGY
METABOLIC SYNDROME
RESEARCH
OpenAccess
AICARinhibitsceramidebiosynthesisinskeletal
muscle
KatherineAErickson1,MelissaESmith1,TamilSAnthonymuthu2,MichaelJEvanson1,EricSBrassfield1,
AimeeEHodson1,MAndrewBressler1,BradenJTucker1,MikaylaOThatcher1,JohnTPrince2,
ChadRHancock3andBenjaminTBikman1*
Abstract
Background:Theworldwideprevalenceofobesityhasleadtoincreasedeffortstofindtherapiestotreat
obesity-relatedpathologies.Ceramideisawell-establishedmediatorofseveralhealthproblemsthatarisefrom
adiposetissueexpansion.Thep
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