An integrated strategy for identification of both sharp and broad peaks from next-generation sequencing data.docVIP

Peng and Zhao Genome Biology 2011,12:120 /2011/12/7/120 RESEARCH HIGHLIGHT An integrated strategy for identication of both sharp and broad peaks from next-generation sequencing data Weiqun Peng * and Keji Zhao * 1 2 See research article: /2011/12/7/r67 Increasingly numerous datasets of genome-wide pro?l- ing of epigenetic modi?cations and chromatin-binding proteins are being generated. Depending on the distri- bution pattern of sequencing reads on the genome, there are virtually two kinds of signals: sharp and di?use