异硫氰酸酯的合成.pdfVIP

第48卷第5期 农 药 Vol. 48, No. 5 2009年5月 AgrochemicAls may 2009 综述 异硫氰酸酯的合成 高中良，刘秀莲，刘东，张丽英 (河北工业大学化工学院，天津300130) 摘要：异硫氰酸酯是一种重要的有机合成中间体，在合成取代硫脲类农药中有广泛应用。综述了以不同起始原 料如叔醇、胺、腈氧化物及异腈化物等合成异硫氰酸酯的方法，并对某些反应机理进行探讨研究。介绍了由二 硫代氨基甲酸盐制备异硫氰酸酯的方法，其中 酸酐的使用因副产物少、后处理简单而有很好的应用前景。 B oc 而一些如微波等新技术的应用对异硫氰酸酯的制备将会起到很好的推动作用。 关键词：异硫氰酸酯；制备；胺；叔醇；异腈化物 中图分类号： 文献标志码： 文章编号： TQ460 A 1006-04 13(2009)05-0322-04 Synthesis of Isothiocyanates GAO Zhong-liang, LIU Xiu-lian, LIU Dong, ZHANG Li-ying (school of chemical engineering hebei University Technology, Tianjin 300130, china) Abstract: isothiocyanates are a class of important organic synthetic intermediates, and have been used extensively in the synthesis of substituted thiourea pesticides. methods for the preparation of isothiocyanates from various starting materials such as tert-alcohol, amine, nitrile oxides and isocyanides were reviewed. some of the reaction mechanism were investigated. introduced the method for the preparation of isothiocyanate from dithiocarbamate. The method which used di-tert-butyl dicarbonate has good application prospects because of the less by-product and simple treatment. And the use of some new technologies such as microwave will play a role in promoting the preparation of isothiocyanates. Key words: isothiocyanates; preparation; amine; tert-alcohol; isocyanide 异硫氰酸酯及其衍生物是一类重要的有机合成中间 N -四正丁基硫氰酸铵都是固体试剂，组成PPh / DD Q/