Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.docVIP

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Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.doc

Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels

Jacobetal.FluidsandBarriersoftheCNS2011,8:23 /content/8/1/23 FLUIDS AND BARRIERS OF THE CNS RESEARCH OpenAccess Arylhydrocarbonreceptor-dependent upregulationofCyp1b1byTCDDanddiesel exhaustparticlesinratbrainmicrovessels AudeJacob1,2?,AnikaMSHartz3,5?,SophiePotin1,2,XavierCoumoul6,SalahYousif1,2,Jean-MichelScherrmann1,2, Bj?rnBauer4,5 andXavierDeclèves1,2* Abstract Background:AhRactivatesthetranscriptionofseveraltargetgenesincludingCYP1B1.Recently,weshowed CYP1B1asthemajorcytochromeP450(CYP)enzymeexpressedinhumanbrainmicrovessels.Here,westudiedthe effectofAhRactivationbyenvironmentalpolluta

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