Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.docVIP
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Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels
Jacobetal.FluidsandBarriersoftheCNS2011,8:23
/content/8/1/23
FLUIDS AND BARRIERS
OF THE CNS
RESEARCH
OpenAccess
Arylhydrocarbonreceptor-dependent
upregulationofCyp1b1byTCDDanddiesel
exhaustparticlesinratbrainmicrovessels
AudeJacob1,2?,AnikaMSHartz3,5?,SophiePotin1,2,XavierCoumoul6,SalahYousif1,2,Jean-MichelScherrmann1,2,
Bj?rnBauer4,5 andXavierDeclèves1,2*
Abstract
Background:AhRactivatesthetranscriptionofseveraltargetgenesincludingCYP1B1.Recently,weshowed
CYP1B1asthemajorcytochromeP450(CYP)enzymeexpressedinhumanbrainmicrovessels.Here,westudiedthe
effectofAhRactivationbyenvironmentalpolluta
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