Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.docVIP

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Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.doc

Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma

Knutsenetal.ClinicalandMolecularAllergy2010,8:5 /content/8/1/5 CMA RESEARCH OpenAccess AssociationofIL-4RAsinglenucleotide polymorphisms,HLA-DRandHLA-DQinchildren withAlternaria-sensitivemoderate-severeasthma AlanPKnutsen1,3*,HariMVijay5,BarbaraKariuki1,3,LuisASantiago2,RalphGraff2,JonathanDWofford1, MaulikRShah1,4 Abstract Background:Asthmaafflicts6%to8%oftheUnitedStatespopulation,andsevereasthmarepresents approximately10%ofasthmaticpatients.SeveralepidemiologicstudiesintheUnitedStatesandEuropehave linkedAlternariasensitivitytobothpersistenceandseverityofasthma.Inordertobegintounderstandgen

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Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.docVIP