Attenuation of fibrosis in vitro and in vivo with SPARC siRNA.docVIP

Wang et al. Arthritis Research Therapy 2010, 12:R60 /content/12/2/R60 RESEARCH ARTICLE Open Access Attenuation of fibrosis Research article in vitro and in vivo with SPARC siRNA Jiu-Cun Wang1,2, Syeling Lai3, Xinjian Guo2, Xuefeng Zhang2, Benoit de Crombrugghe4, Sonali Sonnylal4, Frank C Arnett2 and Xiaodong Zhou*2 Abstract Introduction: SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases. The purpose of this study was to examine whether inhibitio