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Autophagy in rat annulus fibrosus cells evidence and possible implications
Shenetal.ArthritisResearchTherapy2011,13:R132
/content/13/4/R132
RESEARCH ARTICLE
OpenAccess
Autophagyinratannulusfibrosuscells:evidence
andpossibleimplications
ChaoShen,JunYan,Lei-ShengJiangandLi-YangDai*
Abstract
Introduction:Programmedcelldeathofintervertebraldisc(IVD)cellsplaysanimportantroleinIVDdegeneration,
buttheroleofautophagy,acloselyrelatedcelldeathevent,inIVDcellshasnotbeendocumented.Thecurrent
studywasdesignedtoinvestigatetheeffectofinterleukin(IL)-1bontheoccurrenceofautophagyofratannulus
fibrosus(AF)cellsandtheinterrelationshipbetweenautophagyandapoptosis.
Methods:RatAFcellswere
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