Aziridine Carboxylates, Carboxamides and Lactones New Methods for Their Preparation and Their Transformation into α- and β-Amino Acid Derivatives.docVIP

293 Molecules 2000,5 Aziridine Carboxylates, Carboxamides and Lactones: New Methods for Their Preparation and Their Transformation into α- and β-Amino Acid Derivatives Robert H. Dodd Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif- sur-Yvette cedex, France Abstract: The preparation of a variety of novel aziridine-γ-lactones (3) from carbohydrates is de- scribed. In contrast to aziridine-2-carboxylates, the lactones react regiospecifically at C-2 with soft nucleophiles to provide optically pure substituted β-amino acid precursors. Hard nuc