B cell depletion in diffuse progressive systemic sclerosis safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial.docVIP
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B cell depletion in diffuse progressive systemic sclerosis safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial
Boselloetal.ArthritisResearchTherapy2010,12:R54
/content/12/2/R54
RESEARCH ARTICLE
OpenAccess
Bcelldepletionindiffuseprogressivesystemic
sclerosis:safety,skinscoremodificationandIL-6
modulationinanuptothirty-sixmonths
follow-upopen-labeltrial
SilviaBosello1,MariaDeSantis1,GinaLama2,CristinaSpanò2,CristianaAngelucci2,BarbaraTolusso1,GigliolaSica2,
GianfrancoFerraccioli1*
Abstract
Introduction:Anover-expressionofCD19hasbeenshowninBcellsofsystemicsclerosis(SSc)andBcellsare
thoughttocontributetotheinductionofskinfibrosisinthetightskinmousemodel.Theaimwastodefinethe
outcomeonsafetyandthechangein
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