B cell targeted therapies.docVIP

Available online /contents/7/S3/S13 Review B cell targeted therapies Edward Keystone Department of Medicine, University of Toronto, Ontario, Canada Corresponding author: Edward Keystone, edkeystone@mtsinai.on.ca Published: 18 May 2005 This article is online at /content/7/S3/S13 ? 2005 BioMed Central Ltd Arthritis Research Therapy 2005, 7(Suppl 3):S13-S18 (DOI 10.1186/ar1738) Abstract suggested four possible mechanisms of action by which anti- CD20 could deplete B cells. First, after the antibody binds to the extracellular domain of the CD20 antigen, it may activate complement an