Beneficial effects of loxapine on agitation and breathing patterns during weaning from mechanical ventilation.docVIP

Sztrymf et al. Critical Care 2010, 14:R86 /content/14/3/R86 RESEARCH Open Access Beneficial effects of loxapine on agitation and Research breathing patterns during weaning from mechanical ventilation Benjamin Sztrymf, Guillaume Chevrel, Fabrice Bertrand, Dimitri Margetis, Dominique Hurel, Jean-Damien Ricard and Didier Dreyfuss* Abstract Introduction: Interruption of sedation during weaning from mechanical ventilation often leads to patient agitation because of withdrawal syndrome. We tested the short-term efficacy and tolerance of loxapine in this situation. Methods: Nineteen mechanically