原创力文档Beta 1 integrin predicts survival in breast cancer a clinicopathological and immunohistochemical study.docVIP
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Beta 1 integrin predicts survival in breast cancer a clinicopathological and immunohistochemical study
dosSantosetal.DiagnosticPathology2012,7:104
/content/7/1/104
RESEARCH
OpenAccess
Beta1integrinpredictssurvivalinbreastcancer:
aclinicopathologicalandimmunohistochemical
study
PetraBarrosdosSantos1*,JulianaSZanetti2,AlfredoRibeiro-Silva2andEduardoICBeltr?o1,3
Abstract
Background:Themainfocusofseveralstudiesconcernedwithcancerprogressionandmetastasisistoanalyzethe
mechanismsthatallowcancercellstointeractandquicklyadaptwiththeirenvironment.Integrins,afamilyof
transmembraneglycoproteins,playamajorroleininvasiveandmetastaticprocesses.Integrinsareinvolvedincell
adhesioninbothcell-extracellularmatr
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