Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyteagarose constructs.docVIP

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Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyteagarose constructs.doc

Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyteagarose constructs

Ramachandranetal.ArthritisResearchTherapy2011,13:R145 /content/13/5/R145 RESEARCH ARTICLE OpenAccess BiomechanicalsignalsandtheC-typenatriuretic peptidecounteractcatabolicactivitiesinducedby IL-1binchondrocyte/agaroseconstructs ManojRamachandran2,PrimAchan2,DonaldMSalter3,DanLBader1andTinaTChowdhury1* Abstract Introduction:ThepresentstudyexaminedtheeffectofC-typenatriureticpeptide(CNP)ontheanabolicand catabolicactivitiesinchondrocyte/agaroseconstructssubjectedtodynamiccompression. Methods:Constructswereculturedunderfree-swellingconditionsorsubjectedtodynamiccompressionwithlow (0.1to100pM)or

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Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyteagarose constructs.docVIP