Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging.docVIP

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Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging.doc

Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging

Zhangetal.FluidsandBarriersoftheCNS2013,10:13 /content/10/1/13 FLUIDS AND BARRIERS OF THE CNS STUDY PROTOCOL OpenAccess Blood-brainbarriertransportofamyloidbeta peptidesineffluxpumpknock-outanimals evaluatedbyinvivoopticalimaging WandongZhang1,2*,HuaqiXiong1,2,3,DebbieCallaghan1,HongLiu1,AimeeJones1,KePei1,4,DorothyFatehi1, EricBrunette1andDanicaStanimirovic1,2 Abstract Background:Aβtransport(flux)acrosstheblood-brainbarrier(BBB)isthoughttocontributetothepathogenesis ofAlzheimer’sdiseaseaswellastoeliminationoftoxicamyloidfromthebrainbyimmunotherapy.SeveralBBB transportershavebeenimplicatedin

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Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging.docVIP