Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimers disease patients effect of polymorphisms in the ABCB1 gene.docVIP
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Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimers disease patients effect of polymorphisms in the ABCB1 gene
vanAssemaetal.EJNMMIResearch2012,2:57
/content/2/1/57
ORIGINAL RESEARCH
OpenAccess
Blood–brainbarrierP-glycoproteinfunctionin
healthysubjectsandAlzheimersdiseasepatients:
effectofpolymorphismsintheABCB1gene
Dani?lleMEvanAssema1*,MarkLubberink2,PatriziaRizzu3,JohnCvanSwieten4,RobertCSchuit5,JonasEriksson2,
PhilipScheltens1,MatthiasKoepp6,AdriaanALammertsma5andBartNMvanBerckel5
Abstract
Background:P-glycoproteinisablood–brainbarriereffluxtransporterinvolvedintheclearanceofamyloid-beta
fromthebrainand,assuch,mightbeinvolvedinthepathogenesisofAlzheimersdisease.P-glycoproteinis
encodedbythehighl
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