Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimers disease patients effect of polymorphisms in the ABCB1 gene.docVIP

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Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimers disease patients effect of polymorphisms in the ABCB1 gene.doc

Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimers disease patients effect of polymorphisms in the ABCB1 gene

vanAssemaetal.EJNMMIResearch2012,2:57 /content/2/1/57 ORIGINAL RESEARCH OpenAccess Blood–brainbarrierP-glycoproteinfunctionin healthysubjectsandAlzheimersdiseasepatients: effectofpolymorphismsintheABCB1gene Dani?lleMEvanAssema1*,MarkLubberink2,PatriziaRizzu3,JohnCvanSwieten4,RobertCSchuit5,JonasEriksson2, PhilipScheltens1,MatthiasKoepp6,AdriaanALammertsma5andBartNMvanBerckel5 Abstract Background:P-glycoproteinisablood–brainbarriereffluxtransporterinvolvedintheclearanceofamyloid-beta fromthebrainand,assuch,mightbeinvolvedinthepathogenesisofAlzheimersdisease.P-glycoproteinis encodedbythehighl

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