Brain-derived neurotrophic factor plasma levels are associated with mortality in critically ill patients even in the absence of brain injury.docVIP
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Brain-derived neurotrophic factor plasma levels are associated with mortality in critically ill patients even in the absence of brain injury
Ritteretal.CriticalCare2012,16:R234
/content/16/6/R234
RESEARCH
OpenAccess
Brain-derivedneurotrophicfactorplasmalevels
areassociatedwithmortalityincriticallyill
patientsevenintheabsenceofbraininjury
CristianeRitter1,2,AlineSMiranda3,ViníciusRenêGiombelli1,CristianeDTomasi1,ClarissaMComim4,
AntonioLucioTeixeira3,Jo?oQuevedo4andFelipeDal-Pizzol1,2*
Abstract
Introduction:Becauseofitsrelevancetothefunctioningofthecentralnervoussystem,brain-derivedneurotrophic
factor(BDNF)hasbeenimplicatedinthepathogenesisofdifferentneuropsychiatricdiseases.WhethertheBDNF
levelcanbeamarkerofbraindysfunctionandthu
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