BRD4 jump-starts transcription after mitotic silencing.docVIP

Voigt and Reinberg Genome Biology 2011,12:133 /2011/12/11/133 RESEARCH HIGHLIGHT BRD4 jump-starts transcription after mitotic silencing Philipp Voigt and Danny Reinberg* their previously developed inducible reporter transgene Abstract array, whose DNA locus and nascent transcripts can be The chromatin adapter BRD4 may be crucial for transmitting epigenetic information by acting as a histone acetylation-dependent gene bookmark and accelerating post-mitotic transcriptional reactivation. simultaneously visualized by ?uorescence microscopy [3]. Upon induction with a Tet-On sys