Bright days for yeast research.docVIP

P?evorovsky and Rallis Genome Biology 2011,12:305 /2011/12/5/305 MEE TING REPORT Bright days for yeast research Martin P?evorovsky* and Charalampos Rallis* Zegerman (Gurdon Institute, University of Cambridge, Abstract UK) showed that substrates of CDK (Sld2, Sld3 and their binding partner Dpb11) and the DDK subunit Dbf4 are limiting factors for replication initiation in budding yeast. Overexpression of these factors led to early initiation of late origins. When such overexpression was combined with deletion of the histone deacetylase Rpd3 it resulted in ?ring of dormant o