Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis.docVIP

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Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis.doc

Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis

Lehmannetal.CriticalCare2012,16:R47 /content/16/2/R47 RESEARCH OpenAccess Cannabinoidreceptor2activationreduces intestinalleukocyterecruitmentandsystemic inflammatorymediatorreleaseinacute experimentalsepsis ChristianLehmann1,2,3*,MandanaKianian1,JuanZhou2,3,IngaKüster2,RiekeKuschnereit2,SaraWhynot2, OrlandoHung2,RomeshShukla2,BrentJohnston3,VladimirCerny2,4,DraganPavlovic5,AlexanderSpassov6and MelanieEMKelly1 Abstract Introduction:Cannabinoidreceptor2(CB2R)expressionisupregulatedduringsepsis.However,thereare conflictingresultsregardingtheeffectsofCB2Rmodulationinthehyperinflammatoryphaseoft

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Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis.docVIP