Capturing the dynamic epigenome.docVIP

Deal and Heniko Genome Biology 2010,11:218 /2010/11/10/218 RE VIE W Capturing the dynamic epigenome Roger B Deal and Steven Heniko * 1 1,2 cytological level, but which must be sufficiently dynamic to allow for access of regulatory factors to the DNA (Figure 1). Although the precise nature of chromatin beyond the level of single nucleosomes is unclear [2], some principles are beginning to emerge, such as the fractal globule large-scale organization of chromosomes, which al