Catecholamine-induced interleukin-10 release a key mechanism in systemic immunodepression after brain injury.docVIP

Review R107 Catecholamine-induced interleukin-10 release: a key mechanism in systemic immunodepression after brain injury Christian Woiciechowsky*, Britta Sch?ning*, Wolfgang R Lanksch*, Hans-Dieter Volk? and Wolf-Dietrich D?cke? Background: Infections after severe brain injury or polytrauma are still a problem, and may be the result of a brain-mediated disturbed systemic immunoreactivity. The mechanism that connects initial brain affection and systemic immunodepression, however, is still poorly understood. Addresses: *Department of Neurosurgery, Charité-Campus Virchow-Klinikum, and ?Insti