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Cerebral microcirculation is impaired during sepsis an experimental study
Tacconeetal.CriticalCare2010,14:R140
/content/14/4/R140
RESEARCH
OpenAccess
Cerebralmicrocirculationisimpairedduring
sepsis:anexperimentalstudy
FabioSilvioTaccone1,FuhongSu1,CharalamposPierrakos1,XinrongHe1,SyrilJames2,OlivierDewitte2,
Jean-LouisVincent1*,DanielDeBacker1
Abstract
Introduction:Pathophysiologyofbraindysfunctionduetosepsisremainspoorlyunderstood.Cerebral
microcirculatoryalterationsmayplayarole;however,experimentaldataarescarce.Thisstudysoughttoinvestigate
whetherthecerebralmicrocirculationisalteredinaclinicallyrelevantanimalmodelofsepticshock.
Methods:Fifteenanesthetized,invasi
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