CHANCE comprehensive software for quality control and validation of ChIP-seq data.docVIP

Diazetal.GenomeBiology2012,13:R98 /2012/13/10/R98 SOFTWARE OpenAccess CHANCE:comprehensivesoftwareforquality controlandvalidationofChIP-seqdata AaronDiaz1,2,AbhinavNellore1,2 andJunSSong1,2,3,4* Abstract ChIP-seqisapowerfulmethodforobtaininggenome-widemapsofprotein-DNAinteractionsandepigenetic modifications.CHANCE(CHip-seqANalyticsandConfidenceEstimation)isastandalonepackageforChIP-seq qualitycontrolandprotocoloptimization.Ouruser-friendlygraphicalsoftwarequicklyestimatesthestrengthand qualityofimmunoprecipitations,identifiesbiases,comparestheuser’sdatawithENCODE’slargecollectionof publishe