Change in Hemoglobin Levels due to Anesthesia in Mice An Important Confounder in Studies on Hematopoietic Drugs.docVIP
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Change in Hemoglobin Levels due to Anesthesia in Mice An Important Confounder in Studies on Hematopoietic Drugs
ChangeinHemoglobinLevelsduetoAnesthesiainMice:
AnImportantConfounderinStudiesonHematopoieticDrugs
AnitaGothelf,PernilleHojman,andJulieGehl
Abstract
Analgesicandanestheticdrugsmayhaveanimpactontheresultsachievedfromanimalexperiments.In
thestudypresentedhere,wetrytoenlightenwhetheranesthesiawithfentanyl/fluniasoneandmidazolam
(HypnormandDormicum) hasaninfluence onmeasurements ofhemoglobin inmice.Inacross-over
study,wehavecomparedhemoglobinlevelsintwogroupsofmice:anesthetizedversusnon-anesthetized
and found significant decrease in hemoglobin levels in the anesthetized group (pG0.05) unrelated
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