Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the Topoisomerase II inhibitor, Etoposide, in rice.docVIP

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Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the Topoisomerase II inhibitor, Etoposide, in rice.doc

Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the Topoisomerase II inhibitor, Etoposide, in rice

Yangetal.BMCPlantBiology2012,12:48 /1471-2229/12/48 RESEARCH ARTICLE OpenAccess ChangesinDNAmethylationand transgenerationalmobilizationofatransposable element(mPing)bytheTopoisomeraseII inhibitor,Etoposide,inrice XuejiaoYang1?,YingjieYu1?,LilyJiang1,XiuyunLin2,ChunyuZhang1,XiufangOu1,KenjiOsabe3andBaoLiu1* Abstract Background:Etoposide(epipodophyllotoxin)isachemicalcommonlyusedasananti-cancerdrugwhichinhibits DNAsynthesisbyblockingtopoisomeraseIIactivity.Previousstudiesinanimalcellshavedemonstratedthat etoposideconstitutesagenotoxicstresswhichmayinducegenomicinstabilityincludingmobilizatio

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Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the Topoisomerase II inhibitor, Etoposide, in rice.docVIP