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Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)
Catteralletal.ArthritisResearchTherapy2010,12:R229
/content/12/6/R229
RESEARCH ARTICLE
OpenAccess
Changesinserumandsynovialfluidbiomarkers
afteracuteinjury(NC
JonathanBCatterall1,ThomasVStabler1,CarlRFlannery2,VirginiaBKraus1*
Abstract
Introduction:Acutetraumainvolvingtheanteriorcruciateligamentisbelievedtobeamajorriskfactorforthe
developmentofpost-traumaticosteoarthritis10to20yearspost-injury.Inthisstudy,tobetterunderstandtheearly
biologicalchangeswhichoccurafteracuteinjury,weinvestigatedsynovialfluidandserumbiomarkers.
Methods:Wecollectedserumfrom11patientswithoutpre-existingost
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