原创力文档Ciliary and non-ciliary expression and function of PACRG during vertebrate development.docVIP
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Ciliary and non-ciliary expression and function of PACRG during vertebrate development
Thumbergeretal.Cilia2012,1:13
/content/1/1/13
RESEARCH
OpenAccess
Ciliaryandnon-ciliaryexpressionandfunctionof
PACRGduringvertebratedevelopment
ThomasThumberger1,3,CathrinHagenlocher2,MatthiasTisler1,TinaBeyer1,NinaTietze1,AxelSchweickert1,
KerstinFeistel2andMartinBlum1*
Abstract
Background:Park2-co-regulatedgene(PACRG)isevolutionarilyhighlyconservedfromgreenalgaetomammals.In
Chlamydomonasandtrypanosomes,thePACRGproteinassociateswithflagella.LossofPACRGresultsinshortened
orabsentflagella.InmousethePACRGproteinisrequiredforspermatogenesis.Thepurposeofthepresentstudy
wastoanalyze(1)theexpressi
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