Cilia, tubby mice, and obesity.docVIP

MukhopadhyayandJacksonCilia2013,2:1 /content/2/1/1 COMMENTARY OpenAccess Cilia,tubbymice,andobesity SaikatMukhopadhyay1,2*andPeterKJackson1 PleaseseerelatedResearcharticlebyLietal.,/content/1/1/21 Abstract Primaryciliahavebeenpreviouslylinkedtothecentralregulationofsatiety.Thetubbymouseischaracterizedby maturity-onsetobesityandblindness.ArecentpaperdemonstratesmoleculardefectsintraffickingofciliaryGPCRs inthecentralneuronsoftubbymice,underscoringtheroleofciliarysignalinginthepathogenesisofthis monogenicobesitysyndrome. Background regulationofsatiety[4].Thus,itisimperativetoachievea Mostneuro