Cilia - the prodigal organelle.docVIP

BealesandJacksonCilia2012,1:1 /content/1/1/1 EDITORIAL OpenAccess Cilia-theprodigalorganelle PhilBeales1*andPeterKJackson2 Cilia are the oldest known cellular organelle, first C.eleganshomologofthePKD1andPKD2polycystins, describedin1675byAnthonyvanLeeuwenhoekinproto- mutatedinhumanpolycystic kidneydisease,tosensory zoa[1].Hedescribedthemas‘incrediblythinfeet,orlittle cilia[11];thelinkofIFT-Bcomponentstomutationsin legs,whichweremovedverynimbly’.Theterm‘cilium’ left-rightasymmetry[12];andthelinkbetweentheIFT- (Latinforeyelash)wasprobablyfirstcoinedbyOttoMul- Bcomplex,