Clinical monitoring and correlates of nephropathy in SIV-infected macaques during high-dose antiretroviral therapy.docVIP

Sanders-Beeretal.AIDSResearchandTherapy2011,8:3 /content/8/1/3 RESEARCH OpenAccess Clinicalmonitoringandcorrelatesofnephropathy inSIV-infectedmacaquesduringhigh-dose antiretroviraltherapy BrigitteESanders-Beer1,3*,YvetteYSpano4,DawnGolighty1,AbigailLara1,DianeHebblewaite1, LourdesNieves-Duran1,LowreyRhodes1,KeithGMansfield2 Abstract Background:InmanypreclinicalAIDSresearchstudies,antiretroviraltherapy(ART)isadministeredto experimentallysimianimmunodeficiency(SIV)-infectedrhesusmacaquesforreductionofviralloadtoundetectable levels.ProlongedtreatmentofmacaqueswithahighdoseofPMPA(9-[2-(r)-(phosp