Clinical Uses of Botulinum Neurotoxins Current Indications, Limitations and Future Developments.docVIP

Toxins 2012, 4, 913-939; doi:10.3390/toxins4100913 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Review Clinical Uses of Botulinum Neurotoxins: Current Indications, Limitations and Future Developments Sheng Chen Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong; E-Mail: sheng.chen@.hk; Tel.: +852-3400-8795; Fax: +852-2364-9932 Received: 13 August 2012; in revised form: 9 October 2012 / Accepted: 12 October 2012 / Published: 19 October 2012 Abstract: Botulinum neurotoxins (BoNTs) cause flaccid paralysis by int