Combinations of physiologic estrogens with xenoestrogens alter calcium and kinase responses, prolactin release, and membrane estrogen receptor trafficking in rat pituitary cells.docVIP
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Combinations of physiologic estrogens with xenoestrogens alter calcium and kinase responses, prolactin release, and membrane estrogen receptor trafficking in rat pituitary cells
Jengetal.EnvironmentalHealth2010,9:61
/content/9/1/61
RESEARCH
OpenAccess
Combinationsofphysiologicestrogenswith
xenoestrogensaltercalciumandkinase
responses,prolactinrelease,andmembrane
estrogenreceptortraffickinginratpituitarycells
Yow-JiunJeng,MikhailKochukov,CherylSWatson*
Abstract
Background:XenoestrogenssuchasalkylphenolsandthestructurallyrelatedplasticbyproductbisphenolAhave
recentlybeenshowntoactpotentlyvianongenomicsignalingpathwaysandthemembraneversionofestrogen
receptor-a.Thoughtheresponsestothesecompoundsaretypicallymeasuredindividually,theyusually
contaminateorganismsthatalready
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