Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution.docVIP

AIDS Research and Therapy BioMedCentral Methodology Open Access Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution Mark D Andrake?1, Joseph Ramcharan?2, George Merkel1, Xue Zhi Zhao3, Terrence R Burke Jr3 and Anna Marie Skalka*1 Address: 1Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA, 2Locus Pharmaceuticals, Inc, Blue Bell, PA, USA and 3Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute,