Comparison of the pharmacokinetics, safety and tolerability of two concentrations of a new liquid recombinant human growth hormone formulation versus the freeze-dried formulation.docVIP

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Comparison of the pharmacokinetics, safety and tolerability of two concentrations of a new liquid recombinant human growth hormone formulation versus the freeze-dried formulation.doc

Comparison of the pharmacokinetics, safety and tolerability of two concentrations of a new liquid recombinant human growth hormone formulation versus the freeze-dried formulation

Liedertetal.BMCClinicalPharmacology2010,10:14 /1472-6904/10/14 RESEARCH ARTICLE OpenAccess Comparisonofthepharmacokinetics,safetyand tolerabilityoftwoconcentrationsofanewliquid recombinanthumangrowthhormone formulationversusthefreeze-driedformulation BerndLiedert1,UlfForssmann1,2,PeterWolna1,MichaelaGolob3,AndreasKovar1* Abstract Background:Somatropinisrecombinanthumangrowthhormone(GH)usedforthetreatmentofgrowthfailurein childrenandGHdeficiencyinadults.Twoconcentrationsofaliquidformulationhavebeendeveloped:5.83and 8.0mg/mL.Thistrialcomparedthepharmacokinetics(PK),safetyandtolerabilityofthes

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Comparison of the pharmacokinetics, safety and tolerability of two concentrations of a new liquid recombinant human growth hormone formulation versus the freeze-dried formulation.docVIP