Computational and statistical approaches to analyzing variants identified by exome sequencing.docVIP

Stitziel et al. Genome Biology 2011,12:227 /2011/12/9/227 RE VIE W Computational and statistical approaches to analyzing variants identied by exome sequencing Nathan O Stitziel , Adam Kiezun and Shamil Sunyaev * 1,2? 2,3? 2,3 process for identifying variants in next-generation sequencing (NGS) studies and then discuss strategies for identifying the causal variant in Mendelian disorders among the total number of variants identi?ed. We also discuss stra