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Computational challenges in the analysis of ancient DNA
Prüfer et al. Genome Biology 2010, 11:R47
/2010/11/5/R47
METHOD
Open Access
Computational challenges in the analysis of Method
ancient DNA
Kay Prüfer*1, Udo Stenzel1, Michael Hofreiter1,2, Svante P??bo1, Janet Kelso1 and Richard E Green1
NeandertalAathnneaelbywisaimseiesstpch,hrDNAoDeadsNreaoAncfanalysistsnext-generationeadrmiswpihcleiosc.fhatnackieesnitn,sequencingtoincaccountluding
Abstract
High-throughput sequencing technologies have opened up a new avenue for studying extinct organisms. Here we
identify and quantify biases introduced by particular characteristics of ancient DNA samples.
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