Copy number variation in Parkinsons disease.docVIP

Toft and Ross Genome Medicine 2010,2:62 /content/2/9/62 MINIRE VIE W Copy number variation in Parkinson’s disease Mathias Toft and Owen A Ross* 1 2 from less than one kilobase (kb) to several megabases (Mb) in size and can be caused by genomic rearrange- ments such as deletions, multiplications, inversions and translocations [2]. e vast majority of CNVs are unbalanced, may be limited to a single gene or include a contiguous set of genes and can either be inherited or caused by de novo