Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells.docVIP

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Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells.doc

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Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells

Available online /content/4/3/184 Research article Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF- B binding activity and TNF- secretion of T cells Dirk Pohlers1, Carsten B Schmidt-Weber2, Angels Franch3, Jürgen Kuhlmann4, Rolf Br?uer5, Frank Emmrich6 and Raimund W Kinne1 1Experimental Rheumatology Unit, Friedrich Schiller University, Jena, Germany 2Swiss Institute of Asthma and Allergy Research (SIAF), Davos, Switzerland 3Faculty of Pharmacy, University of Barcelona, Barcelona, Spain 4Max Planck Institute of Molecular Physiology, Dortmund, Germany 5Institute of Pathology, Friedrich Schiller University, Jena, Germany 6Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Leipzig, Germany Correspondence: Raimund W Kinne, MD, Experimental Rheumatology Unit, Friedrich Schiller University, Bachstr 18, D-07740 Jena, Germany. Tel: +49 3641 657150; fax: +49 3641 657152, e-mail: Raimund.W.Kinne@rz.uni-jena.de Received: 23 July 2001 Arthritis Res 2002, 4:184-189 Revisions requested: 9 October 2001 Revisions received: 5 November 2001 Accepted: 8 November 2001 Published: 8 January 2002 This article may contain supplementary data which can only be found online at /content/4/3/184 ? 2002 Pohlers et al., licensee BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract The aim of this study was to analyze the differential effects of three anti-CD4 monoclonal antibodies (mAbs) (with distinct epitope specifities) in the treatment of rat adjuvant arthritis (AA) and on T-cell function and signal transduction. Rat AA was preventively treated by intraperitoneal injection of the anti-CD4 mAbs W3/25, OX35, and RIB5/2 (on days –1, 0, 3, and 6, i.e. 1 day before AA induction, on the day of induction [day 0], and thereafter). The effects on T-cell reactivity in vivo (delayed-type hypersensitivity), ex vivo (concanavalin-